منابع مشابه
Asymmetric ring structure of Vps4 required for ESCRT-III disassembly
The vacuolar protein sorting 4 AAA-ATPase (Vps4) recycles endosomal sorting complexes required for transport (ESCRT-III) polymers from cellular membranes. Here we present a 3.6-Å X-ray structure of ring-shaped Vps4 from Metallosphera sedula (MsVps4), seen as an asymmetric pseudohexamer. Conserved key interface residues are shown to be important for MsVps4 assembly, ATPase activity in vitro, ESC...
متن کاملPotassium Channels Some Assembly Required
(Shi et al., 1996, and references therein). In the heart Many types of channels and receptors are expressed and the ear, a single-spanning transmembrane protein, in the nervous system, contributing to the complex and minK, coassembles with KvLQT1 tetramers to form a diverse functional repertoires of neurons. Regulation of delayed rectifier that plays an essential role in repolartranscription an...
متن کاملRotavirus genome replication: Some assembly required
1 Virginia Tech Carilion School of Medicine and Research Institute, Roanoke, Virginia, United States of America, 2 Translational Biology, Medicine, and Health Graduate Program, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia, United States of America, 3 Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virgin...
متن کاملTransformational Pattern System - Some Assembly Required
In the context of Model Driven Architecture (MDA), most model transformation mechanisms aim for rigorously and unambiguously defined, fully automatic transformations. We argue that such techniques, even when fully mature, are not applicable in all cases of software development. These difficult cases would benefit from flexible and semi-automatic open transformations. We present a mechanism, so ...
متن کاملSome assembly required: Redefining the mitotic checkpoint.
The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation. Here we suggest, in light of historical and more recent evidence, that this signaling system monitors kinetochore attachment and spindle assembly by two distinct, but functionally overlapping, pathways.
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ژورنال
عنوان ژورنال: Nature
سال: 2020
ISSN: 0028-0836,1476-4687
DOI: 10.1038/d41586-020-00359-z